Coming off HRT drugs, oestrogen only, progestin only and testosterone
It is safe to come off HRT drugs cold turkey, unlike many drugs, but symptoms can come back.
It is far gentler on the body to reduce the HRT slowly, always using the progesterone whilst doing so. The progesterone normally counteracts any withdrawal symptoms if this route is followed. It's best to use the progesterone for at least a month before attempting to reduce the HRT dose.
How Much Progesterone Cream to Use
The cream can be used at any time of the day and, if preferred, on more than one occasion, but no less than twice a day, as progesterone levels drop after about 13 hours.
It can be applied to any part of the body and does not have to be used only on the thin skinned areas as is sometimes recommended. The skin comprises 95% kerotinocytes, which have a plentiful supply of progesterone receptors, even the hair follicles absorb it well.
Progesterone application methods
There are various method that can be used to deliver progesterone:
- subcutaneous implants
- vaginal tablet
- buccal drops
- oral caps
- oils and creams
How to use NatPro Progesterone creamLearning how to use progesterone cream is not difficult for a woman once she understands it in relation to her cycle. Depending on the severity of the symptoms, women should use between 100-200mg/day.
For men its even easier... anytime, anywhere! Men should use between 10-100mg/day
Historically dosed via injection, suppository, or troche, progesterone is now available in several additional delivery modes.
Of interest is the increase over the last decade in the delivery of hormones through the skin, with various effective modes of application including patches, creams, and gels.
Historically, progesterone (eg Natpro) and synthetic progestins have been lumped together with respect to their safety profiles, although they are very different in their molecular structure and effects.[This is discussed in the section on Bioidentical (Natural) Progesterone vs Synthetic Progestins.]
1. - The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy? Holtorf K. Postgrad Med 2009;121(1):1-13. This literature review presents the substantial evidence for the safety and efficacy of bioidentical hormone therapy, including estradiol, estriol, and Progesterone, which shows that it presents lower risks for breast cancer and cardiovascular disease than synthetic or animal-derived hormones. Studies show that progestins have a number of negative effects on the cardiovascular system and an association with breast cancer risk that can be avoided by using bioidentical progesterone. Not available on Pubmed
Each tube contains 60 grams (2 oz) of cream and 2000mg of progesterone
A single tube, at the minimum dose of 100mg/3ml is sufficient for 20 days - see here.
Natpro cream has a concentration of 3.33% progesterone or 33.33 milligrams per gram
Each tube comes with instructions