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How Much Progesterone Cream to Use

The cream can be used at any time of the day and, if preferred, on more than one occasion, but no less than twice a day, as progesterone levels drop after about 13 hours.

It can be applied to any part of the body and does not have to be used only on the thin skinned areas as is sometimes recommended. The skin comprises 95% kerotinocytes, which have a plentiful supply of progesterone receptors, even the hair follicles absorb it well.

Please note the amount suggested is a guide only as each individual is different. It’s only by trial and error that the correct amount is found. Another point to remember is that stress drops progesterone levels sharply so apply more to prevent the return of symptoms.

Progesterone should always be used dependant on symptoms and not on ‘dose’. If symptoms are severe more will be needed, if mild then less.

Generally between 100-200mg/day of progesterone (that is 3ml to 6ml of cream) is needed.

Please note... The figures below showing quantities of progesterone cream are based on a concentration of 3.33% progesterone as is the case with a 2oz (60 gram) tube of Natpro cream containing 2000mg (2 grams) of progesterone.

Women dosage of progesterone cream

  1. Menstruating
    • if a cycle is present apply the cream twice daily from ovulation for the next 14 days, bleeding should occur within a day or two. The luteal phase is always 12-14 days in all women, any less and it’s known as a ‘defective luteal phase’ Cycles vary from 21 days to 36 days. For instance in a 21 day cycle the cream should be used from day 8 for 14 days, if a 28 day cycle from day 15 for 14 days, and if a 36 day cycle from day 22 for 14 days
  2. Peri or post Menopausal, Hysterectomy, Oophorectomy, Pre-pubertal, Pubertal
    • if there is no cycle, or an erratic one too difficult to follow, apply the cream twice daily. There is no need for a break as some suggest, although some women prefer to have one. Either is fine.
  3. Severe symptoms
    • hot flushes Use at least 400mg/day for 4-5 days, this generally stops them. It’s best to apply the cream hourly
    • heavy, continual bleeding 400-600mg/day from 1 to 3 months, ignoring the cycle. When the bleeding has stopped, slowly reduce the cream until bleeding occurs again, then discontinue the cream for 14 days. Then start again from day 15 for 14 days. Over the coming months the natural cycle length will assert itself. It’s best to apply the cream hourly
    • a multitude of bad symptoms Use a minimum of 200mg/day following the cycle, more might be needed. If symptoms return during the break, then continue applying the cream twice daily or more frequently until they resolve. Once they have then begin following the cycle again.

Men dosage of progesterone cream

Use from 10 to 100mg/day of progesterone (that is 0.3ml to 3 ml of cream). It’s best applied twice a day.
  • 1 ml (1/5th tsp) of Natpro cream contains 33.3mg of progesterone
  • 2ml (2/5th tsp) contains 66.6mg of progesterone
  • 3ml (3/5th tsp) contains 100mg of progesterone
  • 4ml (4/5th tsp) contains 133.2mg progesterone
  • 5ml (1tsp) contains 166.5mg progesterone
  • 1/8th teaspoon (0.625ml) contains 20.8mg progesterone
  • 1/4tsp (1.25ml) contains 41.6mg
  • 1/2tsp (2.5ml) contains 83.2mg
  • 3/4tsp (3.75ml) contains 124.8mg progesterone
  • 1tsp (5ml) contains 166.5mg progesterone
  • 1ml (1/5th tsp) will cover both feet and both legs, or both arms, stomach and breasts.

See here for full details on...

How to use progesterone cream Natpro

Rub the required amount of cream thoroughly into the skin on any part of the body.

Important note for women... If you have been on HRT (hormone replacement therapy) or have a naturally high level of estrogen, progesterone will make you more sensitive to the estrogen in your body. Because of this, for the first two or three months the symptoms caused by excessive estrogen may affect you. If this is the case it is advisable to increase the daily application of progesterone cream, with the advice of your health specialist, until these symptoms have gone.

The main symptoms of excessive estrogen are...

  • breast tenderness

  • bloating/weight gain from water retention

  • spotting or a temporary reappearance of your periods

  • headaches/migraines/dizziness

  • heart palpitations

  • hypoglycemia

  • aches and pains or bruising

  • depression

  • tiredness/chronic fatigue

  • hot flushes

  • mood swings

  • anger

  • skin problems

  • nausea

Before using any progesterone cream it is important to read this page first…

'Estrogen Dominance'

If you are on HRT and wish to discontinue it, the gentlest course is to taper off taking the pills/patches/inserts over a period of 2-6 months. Adjust the tapering off period according to the severity of previous symptoms and how long the HRT was taken. See here for full details...

'Coming off HRT'

For more information on what are often, but wrongly, perceived as progesterone side effects click here.

Simple Progesterone Test

An elevated progesterone level induces an increase in body temperature. Women can measure their temperature by using a thermometer. A rise in progesterone is indicated by about a 0.4 degree Fahrenheit increase and a fall of progesterone, triggering menstruation, indicated by a decrease in temperature.

A thermometer can also help in determining if you are progesterone deficient during pre-menopause years. (Post menopause women are not ovulating and menstruating and have constantly low progesterone levels so progesterone level changes will not occur.) Your temperature should rise at ovulation and remain high until a day or two so before the end of the cycle and the start of menstruation. Fluctuations may occur due to a "double ovulation". Although this is rare it is possible within three days of initial ovulation or due to sickness.

If your temperature never rises (indicating no ovulation) or consistently drops several days after ovulation and stays low for days thereafter it is very probable that your progesterone levels are not being adequately maintained. Low progesterone levels can contribute to miscarriages and osteoporosis and numerous other symptoms of estrogen dominance. To verify your findings the only reliable method is saliva hormone testing.

"...saliva hormone testing is more convenient, less stressful, more cost-effective, and more representative of the bioavailable fraction of hormones in blood than serum hormone testing. When hormones are delivered topically, serum hormone testing grossly underestimates the bioavailable fraction of hormones in blood and tissue hormone uptake and response..." Dr David Zava.

A General Observation about drugs

Some drugs may be dispensed with once progesterone therapy has been started, most notably the anti-depressants. Always taper off slowly and with the advice of your health specialist.

Any additional stress, good or bad, can cause your symptoms to recur. If this should happen then increase the daily application until they have gone.

If you would like to find out more about progesterone therapy please click here and follow the links to usage info.

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